- Title
- Midsagittal corpus callosum area and conversion to multiple sclerosis after clinically isolated syndrome: a multicentre Australian cohort study
- Creator
- Odenthal, Cara; Simpson Jr, Steve; Coulthard, Alan; Ausimmune AusLong Investigator Groups,; Williams, David; Lechner-Scott, Jeannette; Oughton, Justin; van der Mei, Ingrid; Rose, Stephen; Fripp, Jurgen; Lucas, Robyn; Taylor, Bruce; Dear, Keith; Ponsonby, Anne-Louise
- Relation
- Funding BodyNHMRCGrant Number1047180 http://purl.org/au-research/grants/nhmrc/1047180
- Relation
- Journal of Medical Imaging and Radiation Oncology Vol. 61, Issue 4, p. 453-460
- Publisher Link
- http://dx.doi.org/10.1111/1754-9485.12570
- Publisher
- Wiley-Blackwell
- Resource Type
- journal article
- Date
- 2017
- Description
- Introduction: Patients presenting with clinically isolated syndrome (CIS) may proceed to clinically definite multiple sclerosis (CDMS). Midsagittal corpus callosum area (CCA) is a surrogate marker for callosal atrophy, and can be obtained from a standard MRI study. This study explores the relationship between CCA measured at CIS presentation (baseline) and at 5 years post presentation, with conversion from CIS to CDMS. The association between CCA and markers of disability progression is explored. Methods: Corpus callosum area was measured on MRI scans at presentation and 5-year review following diagnosis of a first demyelinating event, or evidence of progressive MS, in 143 participants in the Ausimmune/AusLong Study. Relationships between CCA (at baseline and follow-up) and clinical outcomes were assessed. Results: Mean CCA at baseline study was 6.63 cm² (SD 1.01). Patients who converted to MS by 5-year review (n = 100) had a significantly smaller mean CCA at follow-up (6.22 vs. 6.74, P = 0.007). Greater CCA reduction was associated with higher annualized relapse rate over follow-up. Conclusion: Baseline CCA obtained from standard MRI protocols may be compared with subsequent MRI examinations as a surrogate for neurodegeneration and cerebral atrophy in patients with MS. This study demonstrates an association between CCA and disability in individuals presenting with CIS who convert to MS.
- Subject
- atrophy; clinically isolated syndrome; corpus callosum; magnetic resonance imaging; multiple sclerosis
- Identifier
- http://hdl.handle.net/1959.13/1396799
- Identifier
- uon:34120
- Identifier
- ISSN:1754-9477
- Language
- eng
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